Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease

In 2020, the WHO established road map for neglected tropical diseases 2021–2030, which aims to control and eradicate 20 diseases, including leishmaniosis Chagas disease. addition, since 2015, has been developing a Global Action Plan on Antimicrobial Resistance. this context, achievement of innovative strategies as an alternative replace conventional therapies is first-order socio-sanitary priority, especially regarding endemic zoonoses in poor regions, such those caused by Trypanosoma cruzi Leishmania spp. infections. scenario, it worth highlighting group natural peptide molecules (AMPs CPPs) that are promising improving therapeutic efficacy against these zoonoses, they avoid development toxicity resistance treatments. This review presents novelties their ability cross whole system cell membranes well stimulate host immune defenses or even serve vectors molecules. The efforts biotechnological sector will make possible overcome limitations antimicrobial peptides through encapsulation functionalization methods obtain approval treatments be used clinical programs eradication